Thursday, April 28, 2016

FIRST: SPERM HAVE BEEN PRODUCED IN VITRO

If confirmed, this is a world first that offers hope to infertile men to have more children one day thanks to reproductive health. For the first time, complete human sperm would have been obtained by culturing in vitro cells taken in the testes of men unable to produce naturally.
In healthy men, these stem cells, called spermatogonia produce male gametes after a differentiation process which takes 72 days. A process called spermatogenesis, that biologists have been trying for fifteen years to reproduce in the laboratory.
But so far, rather than full sperm, they had managed to get the abnormal form gametes, headless or without flagella (the "tail" that allows them to swim to the egg).

A SECRET TECHNIQUE OF CELL THERAPY HAS ACHIEVED COMPLETE SPERM

This is now done! In any case, this announcement was made ​​this morning startups Kallistem, after the Institute of Functional Genomics of Lyon . At the origin of this biological feat, researchers Philippe Durand (director Kallistem) and Marie-Hélène Perrard (CNRS and Kallistem), in collaboration with engineering polymer materials Laurent David (professor at the University Claude Bernard).
How do they do it? Only available the information provided by the company because no scientific studies detailing these results has been posted yet. Kallistem has developed a cell therapy device called Artistem, patent protected since late June.

IN THE BIOREACTOR, SPERMATOGENESIS IS REPRODUCED AS IN THE HUMAN BODY

This is a "bioreactor", a tube of flexible polymer of a centimeter in diameter, filled with a hydrogel containing water and chitosan - a substance obtained from chitin, which comprises the exoskeleton of crustaceans.
In this bioreactor, biologists are inserting collected tissue in the testes, called seminiferous tubules: this is where spermatogonia develop into sperm. To reproduce this natural process, it ensures that the architecture of the seminiferous tubules, crowded against each other, be maintained as in the human body.
After 72 days incubation at 33 ° C and in a suitable culture medium at a pH of 7.2 to 7.4, spermatogenesis is complete and sperm were formed.

MANY TESTS ARE NEEDED

But beware: before declaring victory, it will prove that sperm grown and are functional -qu'ils manage to fertilize an egg - and they are used to generate embryos and healthy babies.
therefore the tests will start, first on rodents, then on human gametes to check these two crucial points. Then the company will begin clinical research by testing with men suffering from infertility.

THE IN VITRO SPERMATOGENESIS WOULD BE A SOLUTION FOR INFERTILITY CASES SO FAR WITHOUT MEDICAL ISSUE

If this technique passes the tests, spermatogenesis in vitro provide a solution to all men unable to conceive by natural means, but have spermatogonia. They are 120,000 in the world to be affected by infertility that technology does not allow for the time to resolve.

Furthermore, this technique could help the boys undergoing chemotherapy to cancer before the age of puberty, so before their testicles do not develop. From fabrics to their testicles, sperm could be grown and then frozen to perform in vitro fertilization later. More than 15 000 children worldwide affected by his chemotherapy that damages their testicles.

Monday, April 18, 2016

SURROGACY: TWO HOMOSEXUALS STUCK IN MEXICO WITH THREE BABIES

Travelling from New Zealand to use the services of two Mexican surrogate mothers who received the eggs of an Argentinian donor, a homosexual couple finally find themselves stuck in Mexico with three babies.

The situation of David and Nicky Leonard Beard is complicated. As the surrogate mothers were already pregnant, they may not be concerned by Mexican legislation which came into force last year, banning homosexuals from accessing the services of a surrogate mother in Mexico. However, another problem is holding them there and promises “to make them spend a fortune to return home”: the Cancun adoption agency, acting as the intermediary, settling medical and legal costs and managing the surrogate mothers, has disappeared with their money.

Since then, “stuck” in Mexico with three babies, they are calling on their New Zealand citizenship to avoid waiting for Mexican papers, and are asking both governments to cut the administrative red tape and allow them to return home. 

Wednesday, April 13, 2016

Sperm: they prefer the winter!

An explanation is found throughout the cold: . Winter is, in Sapiens, the mating season 1Because the figures of the National Institute of Demographic Studies (INED) show unambiguous: the period when more children are born from July to October, with a peak in September.
Especially around 23 September, where births are twice as likely than a normal day, but that peak one has a very special explanation, since it corresponds to concepts of Eve, the night of New Year festivities !
Apart from this feast day , simply subtract nine months birthday to find that lots of little Jesus are designed in winter. Because it is cold and couples looking to keep warm in the arms of one another?
Science, which never satisfied appearances, has recently been a much better explanation! One explanation lies in one word: sperm. For Israeli researchers made the finding that male reproductive cells have a strong preference for the winter season: it makes them strong ...!
That was in 2013, at University Medical Center Soroka (Beer-Sheva, Israel) . The protocol? It covered nearly 6500 samples of sperm of men who had consulted the procreation aid department with their partner.
MORE SPERM, BETTER TRAINED AND MORE MOBILE
The result ? In winter, in healthy men, the sperm were more numerous, better trained and more particularly mobile! This last feature is crucial since only a very small number of sperm can swim fast enough to reach the egg of the mother.
However, while in spring and summer, these high-performance swimmers were only 3.5 to 4% in the samples studied, in the fall, they reached 4.9% and 5% ... in winter! An increase of 43% compared to the spring.
Who would have suspected that male gametes are at their best in the cold season! But the facts are there: winter is conducive to reproduction, paternal side. And logically, births registered in the same Israeli hospital were significantly higher in the months from July to October, nine months after the cold season.
CHANGES IN THE SUNSHINE COULD BE THE CAUSE OF THE PHENOMENON
Of course, one question burns the lips: what may well hold this seasonal variation in sperm quality?Las biologists do not really explain. However, as noted by Dr. Jacques Auger, reproduction biologist at the Cochin Hospital (Paris) , the phenomenon is known since the early 2000s!
A study published in 2001 and conducted in several European cities (Paris, Edinburgh, Copenhagen ...), but on a smaller number of men in the Israeli study had found a better sperm quality winter: sperm concentrations were 30% higher than it was!
"This could be due to variations in sunshine during the season , which would influence the hormones and so on sperm production ... but there is still no proof" , explains the researcher.
Better understanding these mechanisms would however be useful, especially for couples struggling to have a child. In France, they account for nearly one in five couples.
-FG

According to Science & Vie Q & A # 14

Friday, April 8, 2016

Why babies all over the world are now sleeping in boxes

Nearly three years ago, the Magazine reported on the Finnish baby box - a starter kit of clothes, sheets and toys the state gives to expectant mothers. The story went viral and was read by 10 million people in 18 months. Now the box idea itself is spreading around the world.
It's a tradition that dates back to the 1930s. Every new mother, regardless of background or income, gets a baby box from the government. The box contains a stash of supplies - bibs, bodysuits, nappies, a sleeping bag, outdoor gear, bathing products - as well as a small mattress. Putting the mattress in the bottom of the box creates the baby's first bed.
It has been credited with helping Finland achieve one of the world's lowest infant mortality rates.


More publicity for the idea quickly followed when the Finnish government gave a baby box to the Duke and Duchess of Cambridge, who were then expecting their first child. Soon afterwards, three fathers in Finland set up a business to supply boxes to customers all over the world. Two women in the US did the same thing. There is now a similar business in the UK, and there may be others elsewhere.

It was such a simple idea, and apparently so effective, that health professionals and social entrepreneurs also wanted to put the box to the test, in some cases teaming up with one of these private suppliers.
Often the contents of the box or the way it is distributed are designed to address local problems, from preventing infection to getting the baby out of the parents' bed, where there may be a risk of suffocation. And in some cases one of the key goals is - as it was in Finland in the early days - to encourage expectant mothers to attend antenatal clinics.
Two South African entrepreneurs, Ernst Hertzog of Action Hero Ventures and marketing executive Frans de Villiers, concluded that a plastic box, that can be used as a bath rather than a bed, was more useful for South African mothers.

But the main objective was to get mothers to antenatal classes, and a trial carried out by a team from Stellenbosch University last year concluded that the Thula Baba Box, as it is known, encourages mothers to attend clinics at an earlier stage of pregnancy, and to attend more frequently. Among other things, this reduces the risk of an HIV-positive mother dying in childbirth, and reduces the risk of HIV being passed from the mother to the baby.
De Villiers and Hertzog are keen for the project to be rolled out across the Western Cape region, and hope that it may one day become a national programme.
"We thought the Finnish box was an amazing example of design that changed a nation,'' says Hertzog. ''We hope that, given some tweaks, our product will have just as much of an impact.''

A doctoral student at Harvard University, Karima Ladhani, had a similar idea about adapting the Finnish box for use in South Asia. She developed the Barakat Bundle project (Barakat means "blessing" in some regional languages) which has now swung into operation at a rural hospital in Jagadiya, India.
The box includes a clean-birth kit to prevent infection during or soon after delivery and a mosquito net to protect babies against malaria.
"We wanted to provide low-cost life saving solutions to new mothers - specifically targeted to causes of preventable infant and maternal mortality," says Ladhani,
But it's not just in developing countries where infant mortality is a concern.
A pilot baby box project is being launched this month at Queen Charlotte's and Chelsea Hospital in London, in collaboration with the US company, Baby Box Co, which says the education component of its programmes is "crucial" to their success.
"We take it for granted people have money for a separate sleeping cot or Moses basket but that might not be the case," says Karen Joash, the consultant obstetrician and gynaecologist behind the plan.
She also thinks the box will enable mothers to keep the baby in the same room with them, because it is so easy to carry, "which is good for bonding," she says.

About 600 boxes will be given to all women who give birth at the hospital over the next few months.
There are dozens of projects under way in US states, but the biggest will launch later this year in Fort Worth, Texas, when all four of the city's hospitals start handing out baby boxes in an attempt to bring down the high infant mortality rate of 7.1 per 1,000 births in 2013. This compared to 5.9 per 1,000 births in the US as a whole.
About 36,000 boxes are expected to be handed out over the next two years. Here a key objective is to encourage parents not to sleep alongside their babies, in the same bed.
"We realised the community wasn't aware infant mortality was a big problem here," says Dyann Daley, of Cook Children's Hospital System.
"Our goal is to provide a box for every live birth in the city and give babies a safe sleeping environment because that is critical to preventing suffocation deaths."

A baby box project is also about to get under way in Australia, in the state of Victoria, and the province of Alberta in Canada has been running a pilot project since October 2015.
Karen Benzies, a professor of nursing at the University of Calgary, says the original intention was to target vulnerable families, but they soon realised "the idea of vulnerability that most people have around low income doesn't necessarily hold true in Alberta". It's a province that has done well out of the oil and gas industry, but when men stay away working on oil rigs for weeks at a time, that creates a different kind of problem - as new mothers are left alone with a new baby.
"Our goal is to support first-time families transitioning from pregnancy to parenting," says Benzies.
A key element of this is mentoring. Every mother and father has to identify a mentor who agrees to be in contact - via phone or in person - about 20 times from when the mother is 32 weeks pregnant to six months after the birth.
"We find in Canada that family and friends see a problem, but don't want to, or are told not to, interfere," says Benzies. "And we wanted to change that."
So far about 50 boxes have been distributed, with 1,500 more ready to go.

Another innovation in the Canadian boxes is a "crib-side assistance" booklet for fathers, to encourage them to bond with the child. Modelled on a car-repair manual it provides a do-it-yourself guide to burping ("You know how good it feels to burp sometimes?") underlines the importance of "fuel" (mother's milk) and explains how to "look under the hood" for those inevitable nappy problems, because "keeping your new model clean and comfortable is important".
The Finnish government says it is aware of the global interest in their baby boxes and often provides consultation to other countries. It now gives presentations at embassies around the world.
But not everyone is convinced the box is the best way forward.
Colin Pritchard, a professor at Bournemouth University who has studied child and infant mortality, says the box system makes some "theoretical sense", as it provides the baby with somewhere to sleep other than the parents' bed and could therefore reduce the number of deaths linked to suffocation.
But he believes the effect will be marginal. Alleviating poverty, stopping parents smoking, and improving education and antenatal care - all these things are more fundamental, he argues, in tackling the problem of infant mortality.

Wednesday, April 6, 2016

Surrogate medicine: what you should know.

If you decide to take to the services of a surrogate mother, it is not superfluous to learn about what is not accepted to be written on sites of reproductive medicine clinics. So, it is about the most important and at the same time rarely voiced features of surrogate medicine in different countries.
States with high living standards: the United States, Czech Republic, UK, etc. It would seem that the living conditions and way of life in such countries logically bound to be higher than in the less developed countries. But everything is rather on the contrary. With the high general level of life, only the least volatile sectors of the population will resort to such earnings as childbearing. The same applies to egg donation. People who have a permanent job, higher education, leading a healthy lifestyle, rarely become surrogate mothers in the countries with developed economies.
The same situation is with the countries, where the vast majority of the population lives below the poverty line. Here you also need to take into account the endemic poor sanitation, dirty water and soil, the inability to fully fed and receive medical care.
The ideal option here is the second world countries, such as Ukraine, Kazakhstan and so on. Fees for surrogacy compared to the average wage are huge there. Subsistence farming prevails, so it is displayed on the nutrition. The average women in these countries have a higher education, a high level of awareness and IQ. It is they who prevail in the programs of surrogacy.
As for the United Kingdom, surrogacy is permitted here only on a voluntary basis. It is assumed that if a woman is ready for you to take this step free of charge, then you know the mother, as well as her way of life.

The image of surrogate mother`s life is of great importance, since it is she who carries your baby his first 9 months of life.

Friday, April 1, 2016

United Kingdom: the number of frozen eggs has tripled in five year

According to a report by the HFEA, the number of women freezing their eggs has tripled in five years. In 2014, 816 women used this technique in an attempt to preserve their fertility and have a child later in life.

The HFEA has listed several reasons behind the freezing of eggs:

·         “The lack of partner is the main reason”: it affects two-thirds of women under the age of 37 who choose this approach, and increases with age,

·         Medical treatment, which may affect fertility,

·         The feeling of not being ready for motherhood whilst being mindful of decreasing fertility,

·         A desire to delay pregnancy for professional reasons (the freezing of eggs has become very popular with working women at key moments in their career.  Moreover, companies such as Apple and Facebook offer this option to employees as a career incentive).

·         The risk of injury or death (especially in the case of members of the armed forces about to be deployed),

·         Sex change.

Since 2001, 3,676 women have frozen their eggs according to figures published by the HFEA. Contrastingly, only 60 babies have been born. As far as President of this organisation, Sally Cheshire, is concerned, “The figures portray a very clear message”: “whereas there has been a big increase in 'social' egg freezing, the number of frozen eggs actually used in treatment is still extremely low”. “It is important that women do not see freezing as a guarantee for future pregnancy,”she added.